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arwa
Junior Member
Joined: 01 Jan 2006
Posts: 4
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 Posted: Sun Jan 01, 2006 5:53 pm Post subject: pyrimidine |
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HI
I try to react chloropyrimidin with amino acids but the reaction is not happen can somebody help me to make this reaction?
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mohamedabass
Probably a bot.
Joined: 05 Jan 2006
Posts: 1
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| Posted: Thu Jan 05, 2006 7:59 am Post subject: re: pyrimidine |
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Dear,
The nature of chloropyrimidine is important to select reaction conditions with aminoacids.
Please inform more about the structure of both reactants and what conditions did you use, hence we may help you as we can
Dr, Mohamed Abass
m.abass@chemist.com
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arwa
Junior Member
Joined: 01 Jan 2006
Posts: 4
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| Posted: Fri Jan 06, 2006 8:35 pm Post subject: |
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Thank you
the position for the chloro at carbon 6 and the amino acids that I made glycine and treptophan, the conditions just make the medium bases to be sure that the attack will be form the nitrogen not from oxygen and reflux.
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guptamohangupta
A really tough bot, or a member.
Joined: 16 Nov 2007
Posts: 2
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| Posted: Sun Nov 18, 2007 2:51 pm Post subject: |
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 hi , u can try some buchwald conditions using Pd(dba)2 or Pd(oAc)2
0.05equalants,xanthophos .05 equalants, Cs2CO3 2 equalants
alll the best
bye 
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